Effects of IL-1 receptor accessory protein on IL-1 binding

被引：23

作者：

Wesche, H ^{[1
]}

Resch, K ^{[1
]}

Martin, MU ^{[1
]}

机构：

[1] Med Hsch Hannover, Inst Mol Pharmakol, D-30625 Hannover, Germany

来源：

FEBS LETTERS | 1998年 / 429卷 / 03期

关键词：

interleukin-1; receptor; IL-1 receptor accessory protein; binding;

D O I：

10.1016/S0014-5793(98)00468-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin-l (IL-I) is an important pro-inflammatory cytokine that exerts its diverse biological functions bg binding to a receptor complex consisting of two transmembrane proteins, type I IL-l receptor (IL-1RI) and IL-1 receptor accessory protein (IL-IRAcP). Both receptor chains are indispensable for IL-l signaling, hut only IL-IRI is able to bind the cytokine, The effects of IL-1RAcP on IL-l binding are unclear. This study shows that although expression of IL-1RAcP does not alter the equilibrium dissociation constant of IL-1, it has an effect on the non-equilibrium binding modus, most likely due to changes in on/off rates. This defines an additional function of IL-1RAcP: it stabilizes the active IL-I receptor complex. (C) 1998 Federation of European Biochemical Societies.

引用

页码：303 / 306

页数：4

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