Gene targeting reveals a hierarchy of transcription factors regulating specification of lymphoid cell fates

被引：67

作者：

Singh, H

机构：

[1] Howard Hughes Medical Institute, University of Chicago, MC 1028, Chicago, IL 60637

来源：

CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 02期

关键词：

DNA-BINDING PROTEIN; B-CELL; CHAIN GENE; PUTATIVE ONCOGENE; NUCLEAR FACTOR; LYMPHOCYTES-B; ETS ONCOGENE; BONE-MARROW; FACTOR BSAP; MB-1; GENE;

D O I：

10.1016/S0952-7915(96)80053-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Specification of B- and T-lymphoid cell fates appears to involve the expression of a shared set of genes encoding recombination proteins and of genes encoding lineage-specific components of antigen receptors. Recent studies using gene targeting have identified transcription factors that are required for the proper specification of lymphoid cell fates. On the basis of these data, a regulatory gene hierarchy which orchestrates the development of lymphoid progenitors from hematopoietic stem cells can be proposed.

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收藏

页码：160 / 165

页数：6

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