Not Community-Associated Methicillin-Resistant Staphylococcus aureus (CA-MRSA)! A Clinician's Guide to Community MRSA - Its Evolving Antimicrobial Resistance and Implications for Therapy

被引：125

作者：

Chua, Kyra ^{[1
,3
]}

Laurent, Frederic ^{[7
]}

Coombs, Geoffrey ^{[4
]}

Grayson, M. Lindsay ^{[1
,2
,5
]}

Howden, Benjamin P. ^{[1
,2
,3
,6
]}

机构：

[1] Austin Hlth, Dept Infect Dis, Heidelberg, Vic 3084, Australia

[2] Austin Hlth, Dept Microbiol, Heidelberg, Vic 3084, Australia

[3] Monash Univ, Dept Microbiol, Clayton, Vic 3168, Australia

[4] WA Royal Perth Hosp, PathWest Lab Med, Dept Microbiol & Infect Dis, Perth, WA, Australia

[5] Univ Melbourne, Dept Med, Parkville, Vic 3052, Australia

[6] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia

[7] Univ Lyon, Hosp Civils Lyon, INSERM, French Natl Reference Ctr Staphylococci,U 851, Lyon, France

来源：

CLINICAL INFECTIOUS DISEASES | 2011年 / 52卷 / 01期

基金：

英国医学研究理事会;

关键词：

PANTON-VALENTINE LEUKOCIDIN; SOFT-TISSUE INFECTIONS; DOUBLE-BLIND; MOLECULAR EPIDEMIOLOGY; RISK-FACTORS; NOSOCOMIAL PNEUMONIA; INTRANASAL MUPIROCIN; MULTIDRUG-RESISTANT; NASAL COLONIZATION; HIGH PREVALENCE;

D O I：

10.1093/cid/ciq067

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There is significant diversity in methicillin-resistant Staphylococcus aureus (MRSA) clones arising in the community worldwide, with considerable geographical differences in typical antimicrobial resistance profiles. Many community clones of MRSA have a non-multidrug resistant antimicrobial profile, providing increased options for empirical and directed therapy of infections caused by these strains. However, the recent description of increasing non-beta lactam resistance in community clones of MRSA, especially USA300, provides a timely warning for clinicians making decisions about therapy for patients potentially infected with these strains. Continued monitoring of global epidemiology and emerging drug resistance data is critical for the effective management of these infections.

引用

页码：99 / 114

页数：16

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