学术探索
学术期刊
学术作者
新闻热点
数据分析
智能评审

Feeding and bone

被引：65
作者：
Walsh, Jennifer S. [1 ]
Henriksen, Dennis B. [2 ]
机构：
[1] No Gen Hosp, NIHR Bone Biomed Res Unit, Ctr Biomed Res, Sheffield S5 7AU, S Yorkshire, England
[2] Sanos Biosci AS, DK-2100 Copenhagen O, Denmark
来源：
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2010年 / 503卷 / 01期
关键词：
Bone turnover; Bone density; Feeding; Gut peptides; Pancreatic peptides; DEPENDENT INSULINOTROPIC PEPTIDE; GASTRIC-INHIBITORY POLYPEPTIDE; GLUCAGON-LIKE PEPTIDE-2; PANCREATIC-POLYPEPTIDE; CIRCADIAN-RHYTHM; PARATHYROID-HORMONE; GROWTH-FACTOR; IN-VITRO; NEUROPEPTIDE-Y; FOOD-INTAKE;
D O I：
10.1016/j.abb.2010.06.020
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要：
Diurnal variation in bone turnover is responsive to feeding and fasting, and feeding results in an acute decrease in bone resorption. These responses may be governed by multiple intermediary systems, and investigation of these systems has led to new potential therapeutic agents for osteoporosis. Here we review the current understanding of the mediators of bone turnover response to feeding, including calcitropic hormones, cortisol, gut peptides and pancreatic peptides. We also discuss the results of clinical trials of analogues of ghrelin, amylin and GLP-2 in the treatment of low bone density, and the potential bone effects of GLP-1 mimetics that are used in the treatment of type 2 diabetes. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：11 / 19
页数：9
相关论文
共 119 条
[1]
HUMAN DISTRIBUTION AND RELEASE OF A PUTATIVE NEW GUT HORMONE, PEPTIDE-YY [J].
ADRIAN, TE ;
FERRI, GL ;
BACARESEHAMILTON, AJ ;
FUESSL, HS ;
POLAK, JM ;
BLOOM, SR .
GASTROENTEROLOGY, 1985, 89 (05) :1070-1077
[2]
AMYLIN INHIBITS BONE-RESORPTION BY A DIRECT EFFECT ON THE MOTILITY OF RAT OSTEOCLASTS [J].
ALAM, ASMT ;
MOONGA, BS ;
BEVIS, PJR ;
HUANG, CLH ;
ZAIDI, M .
EXPERIMENTAL PHYSIOLOGY, 1993, 78 (02) :183-196
[3]
Hypothalamic control of bone formation: Distinct actions of leptin and Y2 receptor pathways [J].
Baldock, PA ;
Sainsbury, A ;
Allison, S ;
Lin, EJD ;
Couzens, M ;
Boey, D ;
Enriquez, R ;
During, M ;
Herzog, H ;
Gardiner, EM .
JOURNAL OF BONE AND MINERAL RESEARCH, 2005, 20 (10) :1851-1857
[4]
Hypothalamic Y2 receptors regulate bone formation [J].
Baldock, PA ;
Sainsbury, A ;
Couzens, M ;
Enriquez, RF ;
Thomas, GP ;
Gardiner, EM ;
Herzog, H .
JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (07) :915-921
[5]
Novel role of Y1 receptors in the coordinated regulation of bone and energy homeostasis [J].
Baldock, Paul A. ;
Allison, Susan J. ;
Lundberg, Pernilla ;
Lee, Nicola J. ;
Slack, Katy ;
Lin, En-Ju D. ;
Enriquez, Ronaldo F. ;
McDonald, Michelle M. ;
Zhang, Lei ;
During, Matthew J. ;
Little, David G. ;
Eisman, John A. ;
Gardiner, Edith M. ;
Yulyaningsih, Ernie ;
Lin, Shu ;
Sainsbury, Amanda ;
Herzog, Herbert .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (26) :19092-19102
[6]
Critical role for peptide YY in protein-mediated satiation and body-weight regulation [J].
Batterham, Rachel L. ;
Heffron, Helen ;
Kapoor, Saloni ;
Chivers, Joanna E. ;
Chandarana, Keval ;
Herzog, Herbert ;
Le Roux, Carel W. ;
Thomas, E. Louise ;
Bell, Jimmy D. ;
Withers, Dominic J. .
CELL METABOLISM, 2006, 4 (03) :223-233
[7]
The gut hormone peptide YY regulates appetite [J].
Batterham, RL ;
Bloom, SR .
MELANOCORTIN SYSTEM, 2003, 994 :162-168
[8]
Inhibition of food intake in obese subjects by peptide YY3-36 [J].
Batterham, RL ;
Cohen, MA ;
Ellis, SM ;
Le Roux, CW ;
Withers, DJ ;
Frost, GS ;
Ghatei, MA ;
Bloom, SR .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (10) :941-948
[9]
Pancreatic polypeptide reduces appetite and food intake in humans [J].
Batterham, RL ;
Le Roux, CW ;
Cohen, MA ;
Park, AJ ;
Ellis, SM ;
Patterson, M ;
Frost, GS ;
Ghatei, MA ;
Bloom, SR .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (08) :3989-3992
[10]
Mechanism of circadian variation in bone resorption [J].
Bjarnason, NH ;
Henriksen, EEG ;
Alexandersen, P ;
Christgau, S ;
Henriksen, DB ;
Christiansen, C .
BONE, 2002, 30 (01) :307-313
12345678910