Effects of cefepime, cefixime and ceftibuten on murine gut colonization by Candida albicans

被引：7

作者：

Maraki, S ^{[1
]}

Barbounakis, E ^{[1
]}

Chatzinikolaou, I ^{[1
]}

Anatoliotakis, N ^{[1
]}

Plataki, M ^{[1
]}

Tselentis, Y ^{[1
]}

Samonis, G ^{[1
]}

机构：

[1] Univ Crete, Div Med, GR-71110 Heraklion, Greece

来源：

CHEMOTHERAPY | 1998年 / 44卷 / 06期

关键词：

Candida albicans; cefepime; cefixime; ceftibuten; gastrointestinal tract;

D O I：

10.1159/000007151

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Crl:CD1(ICR) BR mice were fed chow containing Candida albicans or regular chow. Both groups were subsequently given either antibiotics or normal saline. Stool cultures were performed before, at the end of treatment and I week after treatment, to determine the effect on the stool yeast concentration. Candida-colonized mice treated with cefepime, cefixime or ceftibuten had higher (however not significantly) counts of the yeast in their stools than control Candida-fed mice treated with saline. A group of Candida-fed mice were treated with ceftriaxone, which is known to increase the yeast stool concentration significantly and served as positive control. Mice fed regular chow and treated with the study drugs or saline did not have any yeasts in their stools. Dissemination of Candida did not occur.

引用

页码：405 / 408

页数：4

共 17 条

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