Facultative endocrine progenitor cells in the adult pancreas

被引：43

作者：

Dor, Yuval ^{[1
]}

Melton, Douglas A. ^{[2
,3
]}

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Cellular Biochem & Human Genet, IL-91120 Jerusalem, Israel

[2] Harvard Stem Cell Inst, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

[3] Harvard Univ, Howard Hughes Med Inst, Cambridge, MA 02138 USA

来源：

CELL | 2008年 / 132卷 / 02期

关键词：

D O I：

10.1016/j.cell.2008.01.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using a unique injury model of the pancreas in mouse, Xu et al. ( 2008) now reveal the involvement of neurogenin3, a marker for embryonic-type endocrine progenitor cells, in the formation of new insulin-producing beta cells. These neurogenin3-positive facultative endocrine progenitor cells in the adult pancreas may be of potential value for treating diabetes.

引用

页码：183 / 184

页数：2

共 11 条

[1] The pancreatic ductal epithelium serves as a potential pool of progenitor cells
Bonner-Weir, S
Toschi, E
Inada, A
Reitz, P
Fonseca, SY
Aye, T
Sharma, A
[J]. PEDIATRIC DIABETES, 2004, 5 : 16 - 22
[2] All β cells contribute equally to islet growth and maintenance
Brennand, Kristen
Huangfu, Danwei
Melton, Doug
[J]. PLOS BIOLOGY, 2007, 5 (07): : 1520 - 1529
[3] Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Dor, Y
Brown, J
Martinez, OI
Melton, DA
[J]. NATURE, 2004, 429 (6987) : 41 - 46
[4] Gu GQ, 2002, DEVELOPMENT, V129, P2447
[5] Cellular sources of new pancreatic β cells and therapeutic implications for regenerative medicine
Halban, PA
[J]. NATURE CELL BIOLOGY, 2004, 6 (11) : 1021 - 1025
[6] Pancreas and beta-cell development: from the actual to the possible
Murtaugh, L. Charles
[J]. DEVELOPMENT, 2007, 134 (03): : 427 - 438
[7] Recovery from diabetes in mice by β cell regeneration
Nir, Tomer
Melton, Douglas A.
Dor, Yuval
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (09) : 2553 - 2561
[8] Rosenberg L, 1998, MICROSC RES TECHNIQ, V43, P337, DOI 10.1002/(SICI)1097-0029(19981115)43:4<337::AID-JEMT8>3.0.CO
[9] 2-U
[10] Growth and regeneration of adult β cells does not involve specialized progenitors
Teta, Monica
Rankin, Matthew M.
Long, Simon Y.
Stein, Geneva M.
Kushner, Jake A.
[J]. DEVELOPMENTAL CELL, 2007, 12 (05) : 817 - 826

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