Activation of antigen-induced lymphocyte proliferation by interleukin-15 without the mitogenic effect of interleukin-2 that may induce human immunodeficiency virus-1 expression

被引:40
作者
Patki, AH
QuinonesMateu, ME
Dorazio, D
YenLieberman, B
Boom, WH
Thomas, EK
Lederman, MM
机构
[1] UNIV HOSP CLEVELAND,CASE WESTERN RESERVE UNIV,DEPT MED,DIV INFECT DIS,SCH MED,CLEVELAND,OH 44106
[2] CLEVELAND CLIN EDUC FDN,CLEVELAND,OH 44106
[3] IMMUNEX RES & DEV CORP,SEATTLE,WA 98101
关键词
cellular proliferation; cytokines; HIV; human; T lymphocytes;
D O I
10.1172/JCI118831
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The newly identified cytokine, IL-15 enhanced antigen-induced proliferation of PBMC obtained from HIV-1-seropositive subjects, When compared to IL-2 which enhanced both spontaneous and antigen-induced lymphocyte proliferative responses, IL-15 rarely increased spontaneous lymphocyte proliferation, Additionally, in cultures of lymphocytes obtained from 15 HIV-1-infected patients with < 300 circulating CD4(+) lymphocytes/mu l IL-15 induced significant HIV-1 expression (46, 21, and 71 pg/ml) in only 3 of 15 experiments and IL-2 induced significant HIV-1 expression (range 16- > 5000 pg/ml) in 11 of 15 experiments (P < 0.01, Fischer's exact test), Simultaneous assays of cytokine-induced spontaneous lymphocyte proliferation and HIV-1 expression revealed similar dose-response relationships for induction of HIV-1 and lymphocyte proliferation by IL-2, Thus, IL-15 helps to correct the impaired proliferative response of CD4(+) lymphocytes from HIV-1-infected persons without the mitogenic effect of IL-2 that also may induce HIV-1 expression.
引用
收藏
页码:616 / 621
页数:6
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