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Positron emission tomography after fetal transplantation in Huntington's disease

被引：51
作者：
Furtado, S
Sossi, V
Hauser, RA
Samii, A
Schulzer, M
Murphy, CB
Freeman, TB
Stoessl, AJ
机构：
[1] Univ British Columbia, Vancouver Hosp & Hlth Sci Ctr, Pacific Parkinsons Res Ctr, Vancouver, BC V6T 2B5, Canada
[2] Univ S Florida, Dept Neurol, Tampa, FL 33620 USA
[3] Univ S Florida, Dept Neurosurg, Tampa, FL 33620 USA
来源：
ANNALS OF NEUROLOGY | 2005年 / 58卷 / 02期
关键词：
D O I：
10.1002/ana.20564
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Huntington's disease (HD) is a progressive disorder with no known cure. We report two-year postoperative positron emission tomography (PET) data from 7 HD patients who underwent intrastriatal fetal transplantation. Patients showed widespread reductions in glucose uptake with no significant change over 2 years. Dopamine receptor binding was significantly reduced in HD striatum. 131 binding did not change significantly following transplantation, but there was a significant loss of D2 binding. These findings may reflect loss of graft viability and/or disease progression. There was no significant relationship between changes in PET and clinical function. In summary, there was no benefit from transplantation.
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收藏
页码：331 / 337
页数：7
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