Take five -: BACE and the γ-secretase quartet conduct Alzheimer's amyloid β-peptide generation

被引：461

作者：

Haass, C ^{[1
]}

机构：

[1] Univ Munich, Dept Biochem, Adolf Butenandt Inst, Lab Alzheimers & Parkinsons Dis Res, D-80336 Munich, Germany

来源：

EMBO JOURNAL | 2004年 / 23卷 / 03期

关键词：

Alzheimer's disease; amyloid beta-peptide; processing; secretases;

D O I：

10.1038/sj.emboj.7600061

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In 1959, Dave Brubeck and Paul Desmond revolutionized modern jazz music by composing their unforgettable Take Five in 5/4, one of the most defiant time signatures in all music. Of similar revolutionary importance for biomedical and basic biochemical research is the identification of the minimal set of genes required to obtain a deadly time bomb ticking in all of us: Alzheimer's disease. It now appears that one needs to Take Five genes to produce a deadly peptide by a proteolytic mechanism, which paradoxically is otherwise of pivotal importance for development and cell fate decisions.

引用

页码：483 / 488

页数：6

共 48 条

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