Transmembrane extracellular matrix-cytoskeleton crosstalk

被引：1761

作者：

Geiger, B ^{[1
]}

Bershadsky, A

Pankov, R

Yamada, KM

机构：

[1] Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel

[2] Natl Inst Craniofacial & Dent Res, Craniofacial Dev Biol & Regenerat Branch, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 11期

关键词：

D O I：

10.1038/35099066

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Integrin-mediated cell adhesions provide dynamic, bidirectional links between the extracellular matrix and the cytoskeleton. Besides having central roles in cell migration and morphogenesis, focal adhesions and related structures convey information across the cell membrane, to regulate extracellular-matrix assembly, cell proliferation, differentiation, and death. This review describes integrin functions, mechanosensors, molecular switches and signal-transduction pathways activated and integrated by adhesion, with a unifying theme being the importance of local physical forces.

引用

页码：793 / 805

页数：13

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