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Genomic imprinting: Implications for human disease

被引：267
作者：
Falls, JG
Pulford, DJ
Wylie, AA
Jirtle, RL
机构：
[1] Duke Univ, Med Ctr, Dept Radiat Oncol, Durham, NC 27710 USA
[2] Zeneca Pharmaceut Ltd, Dept Safety Med, Cheshire, England
来源：
AMERICAN JOURNAL OF PATHOLOGY | 1999年 / 154卷 / 03期
关键词：
D O I：
10.1016/S0002-9440(10)65309-6
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Genomic imprinting refers to an epigenetic marking of genes that results in monoallelic expression. This parent-of-origin dependent phenomenon is a notable exception to the laws of Mendelian genetics. Imprinted genes are intricately involved in fetal and behavioral development. Consequently, abnormal expression of these genes results In numerous human genetic disorders including carcinogenesis. This paper reviews genomic imprinting and its role in human disease. Additional information about imprinted genes can be found on the Genomic Imprinting Website at http://www.geneimprint.com.
引用
收藏
页码：635 / 647
页数：13
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