Live attenuated SIV - a model of a vaccine for AIDS

被引：24

作者：

Almond, N ^{[1
]}

Stott, J ^{[1
]}

机构：

[1] Natl Inst Biol Stand & Controls, Div Retrovirol, Potters Bar ENO 3QG, Herts, England

来源：

IMMUNOLOGY LETTERS | 1999年 / 66卷 / 1-3期

关键词：

AIDS; vaccines; SIV; attenuation;

D O I：

10.1016/S0165-2478(98)00153-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The experimental infection of macaques with simian immunodeficiency virus (SIV) has provided strong evidence that it may be possible to develop a vaccine against AIDS. Live attenuated SIV vaccines have been found to confer the most potent protection against challenge with a variety of pathogenic viruses. This article summarizes the work performed at NIBSC to characterize the protection conferred by live attenuated SIV and to identify mechanisms of vaccine protection. The results of these experiments are discussed in conjunction with observations from related studies made by other groups. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：167 / 170

页数：4

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