A genomic-systems biology map for cardiovascular function

被引：140

作者：

Stoll, M

Cowley, AW

Tonellato, PJ

Greene, AS

Kaldunski, ML

Roman, RJ

Dumas, P

Schork, NJ

Wang, ZT

Jacob, HJ

机构：

[1] Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Human & Mol Genet Ctr, Milwaukee, WI 53226 USA

[3] Case Western Reserve Univ, Cleveland, OH 44106 USA

[4] Med Coll Wisconsin, Bioinformat Res Ctr, Milwaukee, WI 53226 USA

[5] Jackson Lab, Bar Harbor, ME 04609 USA

[6] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

来源：

SCIENCE | 2001年 / 294卷 / 5547期

关键词：

D O I：

10.1126/science.1062117

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

With the draft sequence of the human genome available, there is a need to better define gene function in the context of systems biology. We studied 239 cardiovascular and renal phenotypes in 113 mate rats derived from an F-2 intercross and mapped 81 of these traits onto the genome. Aggregates of traits were identified on chromosomes 1, 2, 7, and 18. Systems biology was assessed by examining patterns of correlations ("physiological profiles") that can be used for gene hunting, mechanism-based physiological studies, and, with comparative genomics, translating these data to the human genome.

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收藏

页码：1723 / 1726

页数：4

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