TGFβ and Retinoic Acid Intersect in Immune-Regulation

被引：46

作者：

Mucida, Daniel ^{[1
]}

Cheroutre, Hilde ^{[1
]}

机构：

[1] La Jolla Inst Allergy & Immunol, La Jolla, CA 92037 USA

来源：

CELL ADHESION & MIGRATION | 2007年 / 1卷 / 03期

关键词：

TGF beta; retinoic acid; Foxp3; TH17; IL-6; mucosal immune regulation; oral tolerance; transcription factors;

D O I：

10.4161/cam.1.3.5062

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Transforming growth factor (TGF beta) prevents T(H)1 and T(H)2 differentiation and converts naive CD4 cells into Foxp3-expressing T regulatory (Treg) cell.(1,2) In sharp contrast, in the presence of pro-inflammatory cytokines, including IL-6, TGF beta not only inhibits Foxp3 expression but also promotes the differentiation of pro-inflammatory IL17-producing CD4 effector T (T(H)17) cells.(3-5) This reciprocal TGF beta-dependent differentiation imposes a critical dilemma between pro- and anti-inflammatory immunity and suggests that a sensitive regulatory mechanism must exist to control TGF beta-driven T(H)17 effector and Treg differentiation. A vitamin A metabolite, retinoic acid (RA), was recently identified as a key modulator of TGF beta-driven-immune deviation capable of suppressing T(H)17 differentiation while promoting Foxp3(+) Treg generation.(6-10)

引用

页码：142 / 144

页数：3

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