Conceptually new chiral tertiary C2 symmetric diamines in asymmetric synthesis

被引：51

作者：

Kizirian, JC

Caille, JC

Alexakis, A

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland

[2] PPG SIPSY, F-49242 Avrille, France

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 49期

关键词：

asymmetric synthesis; diamines; organolithiums; imines; C-2; symmetry;

D O I：

10.1016/j.tetlet.2003.09.171

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New chiral diamines were prepared, based on the cyclohexane diamine core. The two different substituents on each nitrogen allow this heteroatom to become a stereogenic center upon chelation with a metal, such as lithium. The enantioselective addition of MeLi to imines. with ee's up to 68%, illustrates the validity of this concept. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：8893 / 8895

页数：3

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