Parahydrogen-induced polarization in imaging:: Subsecond 13C angiography

被引:288
作者
Golman, K [1 ]
Axelsson, O [1 ]
Jóhannesson, H [1 ]
Månsson, S [1 ]
Olofsson, C [1 ]
Petersson, JS [1 ]
机构
[1] Nycomed Innovat AB, MEDEON, SE-20512 Malmo, Sweden
关键词
parahydrogen-induced polarization; diabatic; hyperpolarized C-13; angiography;
D O I
10.1002/mrm.1152
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
High nuclear spin polarization of C-13 was reached in organic molecules. Enhancements of up to 10(4), compared to thermal polarization at 1.5 T, were achieved using the parahydrogen-induced polarization technique in combination with a field cycling method. While parahydrogen has no net polarization, it has a high spin order, which is retained when hydrogen is incorporated into another molecule by a chemical reaction. By subjecting this molecule to a sudden change of the external magnetic field, the spin order is transferred into net polarization. A C-13 angiogram of an animal was generated in less than a second. (C) 2001 Wiley-Liss, Inc.
引用
收藏
页码:1 / 5
页数:5
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