High-Order Multiblock Copolymers via Iterative Cu(0)-Mediated Radical Polymerizations (SET-LRP): Toward Biological Precision

被引：294

作者：

Soeriyadi, Alexander H. ^{[1
]}

Boyer, Cyrille ^{[1
]}

Nystroem, Fredrik ^{[1
]}

Zetterlund, Per B. ^{[1
]}

Whittaker, Michael R. ^{[1
]}

机构：

[1] Univ New S Wales, Ctr Adv Macromol Design, Sch Chem Engn, Sydney, NSW 2052, Australia

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 29期

基金：

澳大利亚研究理事会;

关键词：

PHASE PEPTIDE-SYNTHESIS; BROMO CLICK CHEMISTRY; METHYL ACRYLATE; ELECTRON-TRANSFER; MACROMOLECULES; STRATEGY; SEQUENCE;

D O I：

10.1021/ja205080u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a new approach for the facile synthesis of high-order multiblock copolymers comprising very short blocks. The approach entails sequential addition of different monomers via an iterative single electron transfer-living radical polymerization technique, allowing nearly perfect control of the copolymer microstructure. It is possible to synthesize high-order multiblock copolymers with unprecedented control, i.e., A-B-C-D-E-etc., without any need for purification between iterative 24 h block formation steps. To illustrate this concept, we report the synthesis of model P(MA-b-MA ... ) homopolymer and P(MA-b-nBuA-b-EA-b-2EHA-b-EA-b-nBuA) copolymer in extremely high yield. Finally, the halide end-group can be modified via "click chemistry", including thiol-bromide click chemistry, sodium methanethiosulfonate nucleophilic substitution, and atom transfer radical nitroxide coupling reaction, to yield functional, structurally complex macromolecules.

引用

页码：11128 / 11131

页数：4

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