Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice

被引：22

作者：

Bignell, E ^{[1
]}

Negrete-Urtasun, S ^{[1
]}

Calcagno, AM ^{[1
]}

Arst, HN ^{[1
]}

Rogers, T ^{[1
]}

Haynes, K ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis, London W12 0NN, England

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 08期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/IAI.73.8.5204-5207.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

While investigating the requirement for phagosomal alkalinization in the host defense against pulmonary aspergillosis, we observed high morbidity of p47(phox-/-) mice infected with pH-insensitive Aspergillus nidulans mutants despite a paucity of fungal growth. Fatal infection also resulted from a normally avirulent p-aminobenzoate auxotroph. This demonstrates that p47(phox-/-) murine immunity contributes significantly to A. nidulans lethality. These data have wider implications for microbial virulence studies with p47(phox-/-) mice.

引用

页码：5204 / 5207

页数：4

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