Paths of convergence: Sirtuins in aging and neurodegeneration

被引：188

作者：

Gan, Li ^{[1
,2
]}

Mucke, Lennart ^{[1
,2
]}

机构：

[1] Gladstone Inst Neurol Dis, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA

来源：

NEURON | 2008年 / 58卷 / 01期

关键词：

D O I：

10.1016/j.neuron.2008.03.015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Members of the sirtuin family of protein deacetylases support and promote longevity in diverse organisms and can extend life span when upregulated. Sirtuin pathways also modulate fundamental mechanisms in aging-related neurodegenerative diseases, including protein aggregation, stress responses, mitochondrial homeostasis, and inflammatory processes. In this minireview, we will discuss how progress in understanding the neurobiology of sirtuins is shedding light on the pathogenesis of these devastating conditions. We will also examine the potential and challenges of targeting sirtuin pathways therapeutically.

引用

页码：10 / 14

页数：5

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