The first regiospecific, enantiospecific total synthesis of 6-oxoalstophylline and an improved total synthesis of alstonerine and alstophylline as well as the bisindole alkaloid macralstonine

被引：38

作者：

Liao, XB ^{[1
]}

Zhou, H ^{[1
]}

Wearing, XZ ^{[1
]}

Ma, J ^{[1
]}

Cook, JM ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Milwaukee, WI 53211 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 16期

关键词：

D O I：

10.1021/ol051208y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Wacker sequence has been modified to rapidly generate ring E of (-)-alstonerine, (+)-6-oxoalstophylline, and (-)-alstophylline via a domino process. This one-pot sequence provides facile entry into the dihydropyranyl enone unit of many Alstonia alkaloids.

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页码：3501 / 3504

页数：4

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