Monosodium 4-amino-1-hydroxy-1,1-butanediyldiphosphonate trihydrate (Alendronate)

被引：38

作者：

Vega, D ^{[1
]}

Baggio, R ^{[1
]}

Garland, MT ^{[1
]}

机构：

[1] UNIV CHILE, FAC CIENCIAS FIS & MATEMAT, DEPT FIS, SANTIAGO, CHILE

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY | 1996年 / 52卷

关键词：

D O I：

10.1107/S0108270196006105

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The cation in the title compound, Na+.C4H12NO7P2-.3H(2)O, has the expected zwitterionic character, with a terminal protonated amine group on one side of the chain and a negatively charged diphosphonate group on the other, the latter interacting with the Na+ ion. The structure is stabilized by a complex hydrogen-bonding scheme, which is found to be weaker than that observed in the free acid.

引用

页码：2198 / 2201

页数：4

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