In vivo assessments of bioabsorbable AZ91 magnesium implants coated with nanostructured fluoridated hydroxyapatite by MAO/EPD technique for biomedical applications

被引:96
作者
Razavi, Mehdi [1 ,2 ,3 ,4 ]
Fathi, Mohammadhossein [1 ,2 ]
Savabi, Omid [3 ]
Vashaee, Daryoosh [5 ]
Tayebi, Lobat [4 ,6 ,7 ]
机构
[1] Isfahan Univ Technol, Dept Mat Engn, Biomat Res Grp, Esfahan 8415683111, Iran
[2] Isfahan Univ Med Sci, Dent Mat Res Ctr, Esfahan, Iran
[3] Isfahan Univ Med Sci, Sch Dent, Torabinejad Dent Res Ctr, Esfahan 8174673461, Iran
[4] Oldahoma State Univ, Helmerich Adv Technol Res Ctr, Sch Mat Sci & Engn, Tulsa, OK 74106 USA
[5] Oldahoma State Univ, Helmerich Adv Technol Res Ctr, Sch Elect & Comp Engn, Tulsa, OK 74106 USA
[6] Marquette Univ, Sch Dent, Dept Dev Sci, Milwaukee, WI 53201 USA
[7] Stanford Univ, Biomat & Adv Drug Delivery Lab, Stanford, CA 94305 USA
来源
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2015年 / 48卷
基金
美国国家科学基金会;
关键词
Bioabsorbable magnesium alloy; Coating; Surface modification; Fluoridated hydroxyapatite; in vivo; DEGRADATION BEHAVIOR; ALLOY; CORROSION; TISSUE; VITRO; NANOCOMPOSITE; SCAFFOLDS; PHOSPHATE; COATINGS; CALCIUM;
D O I
10.1016/j.msec.2014.11.020
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
082905 [生物质能源与材料]; 100103 [病原生物学];
摘要
Although magnesium (Mg) is a unique biodegradable metal which possesses mechanical property similar to that of the natural bone and can be an attractive material to be used as orthopedic implants, its quick corrosion rate restricts its actual clinical applications. To control its rapid degradation, we have modified the surface of magnesium implant using fluoridated hydroxyapatite (FHA: Ca-10(PO4)(6)OH2 - xFx) through the combined micro-arc oxidation (MAO) and electrophoretic deposition (EPD) techniques, which was presented in our previous paper. In this article, the biocompatibility examinations were conducted on the coated AZ91 magnesium alloy by implanting it into the greater trochanter area of rabbits. The results of the in vivo animal test revealed a significant enhancement in the biocompatibility of FHA/MAO coated implant compared to the uncoated one. By applying the FHA/MAO coating on the AZ91 implant, the amount of weight loss and magnesium ion release in blood plasma decreased. According to the histological results, the formation of the new bone increased and the inflammation decreased around the implant. In addition, the implantation of the uncoated AZ91 alloy accompanied by the release of hydrogen gas around the implant; this release was suppressed by applying the coated implant. Our study exemplifies that the surface coating of magnesium implant using a bioactive ceramic such as fluoridated hydroxyapatite may improve the biocompatibility of the implant to make it suitable as a commercialized biomedical product. Published by Elsevier B.V.
引用
收藏
页码:21 / 27
页数:7
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