Prognostic implications of estrogen receptor 1 and vascular endothelial growth factor A expression in primary gallbladder carcinoma

被引:27
作者
Zhang, Ling-Qiang [1 ]
Xu, Xin-Sen [1 ]
Wan, Yong [1 ]
Song, Si-Dong [1 ]
Wang, Rui-Tao [1 ]
Chen, Wei [1 ]
Wang, Zhi-Xin [1 ]
Chang, Hu-Lin [1 ]
Wei, Ji-Chao [1 ]
Dong, Ya-Feng [2 ]
Liu, Chang [1 ]
机构
[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Coll Med, Dept Hepatobiliary Surg, Xian 710061, Shaanxi Provinc, Peoples R China
[2] Univ Kansas, Sch Med, Dept Obstet & Gynecol, Kansas City, KS 66160 USA
基金
中国国家自然科学基金;
关键词
Gallbladder carcinoma; Estrogen receptor 1; Vascular endothelial growth factor A; BREAST-CANCER PATIENTS; BILIARY-TRACT CANCERS; GENE-EXPRESSION; PROLIFERATION; BETA; ANGIOGENESIS; SECRETION; ESTRADIOL; TAMOXIFEN; STIMULATE;
D O I
10.3748/wjg.v21.i4.1243
中图分类号
R57 [消化系及腹部疾病];
学科分类号
100201 [内科学];
摘要
AIM: To investigate the prognostic significance of estrogen receptor 1 (ER1) and vascular endothelial growth factor A (VEGF-A) expression in primary gallbladder carcinoma (GBC) to identify new prognostic markers for this malignancy. METHODS: Using immunohistochemistry, we investigated ER1 and VEGF-A expression in 78 GBC and 78 cholelithiasis (CS) tissues. The results were correlated with clinicopathological features. Univariate and multivariate analyses were performed to evaluate the relationship between ER1 and VEGF-A expression and patients' prognosis. Further Kaplan-Meier survival analysis was also performed. RESULTS: ER1 and VEGF-A expression was significantly higher in GBC compared with CS (47/78 vs 28/78, P < 0.05; 51/78 vs 33/78, P < 0.05). ER1 expression was correlated with gender (P < 0.05) and VEGF-A expression was correlated with tumor differentiation in GBC patients (P < 0.05). In univariate analysis, age and tumor node metastasis (TNM) stage were factors associated with GBC prognosis (P < 0.05). Although there was no statistical difference between the expression of ER1 or VEGF-A and overall survival, the high expression of ER1 combined with VEGF-A predicted a poor prognosis for GBC patients (16.30 +/- 1.87 vs 24.97 +/- 2.09, log-rank P < 0.05). In multivariate analysis, combined expression of ER1 and VEGF-A and TNM stage were independent prognostic factors for GBC patients (P < 0.05). CONCLUSION: Combined expression of ER1 and VEGF-A is a potential prognostic marker for GBC patients. Clinical detection of ER1 and VEGF-A in surgically resected GBC tissues would provide an important reference for decision-making of postoperative treatment programs.
引用
收藏
页码:1243 / 1250
页数:8
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