共 40 条
Ligand-induced formation of triple helices with antiparallel third strands containing G and T
被引:28
作者:

Escude, C
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机构: MUSEUM NATL HIST NAT, BIOPHYS LAB, CNRS URA 481, INSERM U201, F-75231 PARIS 05, FRANCE

Sun, JS
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机构: MUSEUM NATL HIST NAT, BIOPHYS LAB, CNRS URA 481, INSERM U201, F-75231 PARIS 05, FRANCE

Nguyen, CH
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机构: MUSEUM NATL HIST NAT, BIOPHYS LAB, CNRS URA 481, INSERM U201, F-75231 PARIS 05, FRANCE

Bisagni, E
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Garestier, T
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Helene, C
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h-index: 0
机构: MUSEUM NATL HIST NAT, BIOPHYS LAB, CNRS URA 481, INSERM U201, F-75231 PARIS 05, FRANCE
机构:
[1] MUSEUM NATL HIST NAT, BIOPHYS LAB, CNRS URA 481, INSERM U201, F-75231 PARIS 05, FRANCE
[2] INST CURIE, SYNTH ORGAN LAB, CNRS URA 1387, F-91405 ORSAY, FRANCE
关键词:
D O I:
10.1021/bi960120c
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
We have examined the effects of benzopyridoindole derivatives on triple helices with antiparallel third strands. Absorption spectroscopy, footprinting, and gel retardation experiments demonstrate that a benzopyridoindole derivative (BePI) is able to induce formation of a triple helix with an antiparallel (G,T)-containing third strand, which does not form in the absence of this ligand. This triple-helical complex is very stable with a half-dissociation temperature as high as 51 degrees C, and its formation is pH independent. Antiparallel oligonucleotides containing thymine and guanine bind strongly to double-helical DNA under physiological conditions in the presence of only 0.5 mu M BePI. Formation of a BePI-stabilized triple helix strongly inhibits cleavage of the target duplex by DNase I.
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页码:5735 / 5740
页数:6
相关论文
共 40 条
[1]
2ND STRUCTURAL MOTIF FOR RECOGNITION OF DNA BY OLIGONUCLEOTIDE-DIRECTED TRIPLE-HELIX FORMATION
[J].
BEAL, PA
;
DERVAN, PB
.
SCIENCE,
1991, 251 (4999)
:1360-1363

BEAL, PA
论文数: 0 引用数: 0
h-index: 0
机构:
CALTECH,DIV CHEM & CHEM ENGN,ARNOLD & MABEL BECKMAN LABS CHEM SYNTH,PASADENA,CA 91125 CALTECH,DIV CHEM & CHEM ENGN,ARNOLD & MABEL BECKMAN LABS CHEM SYNTH,PASADENA,CA 91125

DERVAN, PB
论文数: 0 引用数: 0
h-index: 0
机构:
CALTECH,DIV CHEM & CHEM ENGN,ARNOLD & MABEL BECKMAN LABS CHEM SYNTH,PASADENA,CA 91125 CALTECH,DIV CHEM & CHEM ENGN,ARNOLD & MABEL BECKMAN LABS CHEM SYNTH,PASADENA,CA 91125
[2]
OLIGONUCLEOTIDE INTERACTIONS .3. CIRCULAR DICHROISM STUDIES OF CONFORMATION OF DEOXYOLIGONUCLEOTIDES
[J].
CANTOR, CR
;
WARSHAW, MM
;
SHAPIRO, H
.
BIOPOLYMERS,
1970, 9 (09)
:1059-&

CANTOR, CR
论文数: 0 引用数: 0
h-index: 0

WARSHAW, MM
论文数: 0 引用数: 0
h-index: 0

SHAPIRO, H
论文数: 0 引用数: 0
h-index: 0
[3]
EFFECT OF A TRIPLER-BINDING LIGAND ON PARALLEL AND ANTIPARALLEL DNA TRIPLE HELICES USING SHORT UNMODIFIED AND ACRIDINE-LINKED OLIGONUCLEOTIDES
[J].
CASSIDY, SA
;
STREKOWSKI, L
;
WILSON, WD
;
FOX, KR
.
BIOCHEMISTRY,
1994, 33 (51)
:15338-15347

CASSIDY, SA
论文数: 0 引用数: 0
h-index: 0
机构: UNIV SOUTHAMPTON, DEPT PHYSIOL & PHARMACOL, SOUTHAMPTON SO9 3TU, HANTS, ENGLAND

STREKOWSKI, L
论文数: 0 引用数: 0
h-index: 0
机构: UNIV SOUTHAMPTON, DEPT PHYSIOL & PHARMACOL, SOUTHAMPTON SO9 3TU, HANTS, ENGLAND

WILSON, WD
论文数: 0 引用数: 0
h-index: 0
机构: UNIV SOUTHAMPTON, DEPT PHYSIOL & PHARMACOL, SOUTHAMPTON SO9 3TU, HANTS, ENGLAND

FOX, KR
论文数: 0 引用数: 0
h-index: 0
机构: UNIV SOUTHAMPTON, DEPT PHYSIOL & PHARMACOL, SOUTHAMPTON SO9 3TU, HANTS, ENGLAND
[4]
OLIGODEOXYRIBONUCLEOTIDE LENGTH AND SEQUENCE EFFECTS ON INTERMOLECULAR PURINE - PURINE - PYRIMIDINE TRIPLE-HELIX FORMATION
[J].
CHENG, AJ
;
VANDYKE, MW
.
NUCLEIC ACIDS RESEARCH,
1994, 22 (22)
:4742-4747

CHENG, AJ
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV TEXAS,MD ANDERSON CANC CTR,DEPT TUMOR BIOL,HOUSTON,TX 77030 UNIV TEXAS,MD ANDERSON CANC CTR,DEPT TUMOR BIOL,HOUSTON,TX 77030

VANDYKE, MW
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV TEXAS,MD ANDERSON CANC CTR,DEPT TUMOR BIOL,HOUSTON,TX 77030 UNIV TEXAS,MD ANDERSON CANC CTR,DEPT TUMOR BIOL,HOUSTON,TX 77030
[5]
MONOVALENT CATION EFFECTS ON INTERMOLECULAR PURINE-PURINE-PYRIMIDINE TRIPLE-HELIX FORMATION
[J].
CHENG, AJ
;
VANDYKE, MW
.
NUCLEIC ACIDS RESEARCH,
1993, 21 (24)
:5630-5635

CHENG, AJ
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV TEXAS, M D ANDERSON CANC CTR, DEPT TUMOR BIOL, 1515 HOLCOMBE BLVD, HOUSTON, TX 77030 USA UNIV TEXAS, M D ANDERSON CANC CTR, DEPT TUMOR BIOL, 1515 HOLCOMBE BLVD, HOUSTON, TX 77030 USA

VANDYKE, MW
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV TEXAS, M D ANDERSON CANC CTR, DEPT TUMOR BIOL, 1515 HOLCOMBE BLVD, HOUSTON, TX 77030 USA UNIV TEXAS, M D ANDERSON CANC CTR, DEPT TUMOR BIOL, 1515 HOLCOMBE BLVD, HOUSTON, TX 77030 USA
[6]
BASE CHANGES AND TRIPLE-HELIX HYBRIDIZATION PROPERTIES OF GT CONTAINING 3RD STRANDS - A SYSTEMATIC STUDY
[J].
CLARENC, JP
;
LEBLEU, B
;
LEONETTI, JP
.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS,
1994, 13 (1-3)
:799-809

CLARENC, JP
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV MONTPELLIER 2, F-34033 MONTPELLIER, FRANCE UNIV MONTPELLIER 2, F-34033 MONTPELLIER, FRANCE

LEBLEU, B
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV MONTPELLIER 2, F-34033 MONTPELLIER, FRANCE UNIV MONTPELLIER 2, F-34033 MONTPELLIER, FRANCE

LEONETTI, JP
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV MONTPELLIER 2, F-34033 MONTPELLIER, FRANCE UNIV MONTPELLIER 2, F-34033 MONTPELLIER, FRANCE
[7]
Alternate strand recognition of double-helical DNA by (T,G)-containing oligonucleotides in the presence of a triple helix-specific ligand
[J].
deBizemont, T
;
DuvalValentin, G
;
Sun, JS
;
Bisagni, E
;
Garestier, T
;
Helene, C
.
NUCLEIC ACIDS RESEARCH,
1996, 24 (06)
:1136-1143

deBizemont, T
论文数: 0 引用数: 0
h-index: 0
机构: MUSEUM NATL HIST NAT, BIOPHYS LAB, CNRS URA 418, INSERM U201, F-75231 PARIS 05, FRANCE

DuvalValentin, G
论文数: 0 引用数: 0
h-index: 0
机构: MUSEUM NATL HIST NAT, BIOPHYS LAB, CNRS URA 418, INSERM U201, F-75231 PARIS 05, FRANCE

Sun, JS
论文数: 0 引用数: 0
h-index: 0
机构: MUSEUM NATL HIST NAT, BIOPHYS LAB, CNRS URA 418, INSERM U201, F-75231 PARIS 05, FRANCE

Bisagni, E
论文数: 0 引用数: 0
h-index: 0
机构: MUSEUM NATL HIST NAT, BIOPHYS LAB, CNRS URA 418, INSERM U201, F-75231 PARIS 05, FRANCE

Garestier, T
论文数: 0 引用数: 0
h-index: 0
机构: MUSEUM NATL HIST NAT, BIOPHYS LAB, CNRS URA 418, INSERM U201, F-75231 PARIS 05, FRANCE

Helene, C
论文数: 0 引用数: 0
h-index: 0
机构: MUSEUM NATL HIST NAT, BIOPHYS LAB, CNRS URA 418, INSERM U201, F-75231 PARIS 05, FRANCE
[8]
NMR-STUDIES OF DNA (R+)N.(Y-)N.(Y+)N TRIPLE HELICES IN SOLUTION - IMINO AND AMINO PROTON MARKERS OF T.A.T AND C.G.C+ BASE-TRIPLE FORMATION
[J].
DELOSSANTOS, C
;
ROSEN, M
;
PATEL, D
.
BIOCHEMISTRY,
1989, 28 (18)
:7282-7289

DELOSSANTOS, C
论文数: 0 引用数: 0
h-index: 0
机构:
COLUMBIA UNIV COLL PHYS & SURG,DEPT BIOCHEM & MOLEC BIOPHYS,NEW YORK,NY 10032 COLUMBIA UNIV COLL PHYS & SURG,DEPT BIOCHEM & MOLEC BIOPHYS,NEW YORK,NY 10032

ROSEN, M
论文数: 0 引用数: 0
h-index: 0
机构:
COLUMBIA UNIV COLL PHYS & SURG,DEPT BIOCHEM & MOLEC BIOPHYS,NEW YORK,NY 10032 COLUMBIA UNIV COLL PHYS & SURG,DEPT BIOCHEM & MOLEC BIOPHYS,NEW YORK,NY 10032

PATEL, D
论文数: 0 引用数: 0
h-index: 0
机构:
COLUMBIA UNIV COLL PHYS & SURG,DEPT BIOCHEM & MOLEC BIOPHYS,NEW YORK,NY 10032 COLUMBIA UNIV COLL PHYS & SURG,DEPT BIOCHEM & MOLEC BIOPHYS,NEW YORK,NY 10032
[9]
BINDING OF TRIPLE HELIX FORMING OLIGONUCLEOTIDES TO SITES IN GENE PROMOTERS
[J].
DURLAND, RH
;
KESSLER, DJ
;
GUNNELL, S
;
DUVIC, M
;
PETTITT, BM
;
HOGAN, ME
.
BIOCHEMISTRY,
1991, 30 (38)
:9246-9255

DURLAND, RH
论文数: 0 引用数: 0
h-index: 0
机构: BAYLOR COLL MED, CTR BIOTECHNOL, THE WOODLANDS, TX 77381 USA

KESSLER, DJ
论文数: 0 引用数: 0
h-index: 0
机构: BAYLOR COLL MED, CTR BIOTECHNOL, THE WOODLANDS, TX 77381 USA

GUNNELL, S
论文数: 0 引用数: 0
h-index: 0
机构: BAYLOR COLL MED, CTR BIOTECHNOL, THE WOODLANDS, TX 77381 USA

DUVIC, M
论文数: 0 引用数: 0
h-index: 0
机构: BAYLOR COLL MED, CTR BIOTECHNOL, THE WOODLANDS, TX 77381 USA

PETTITT, BM
论文数: 0 引用数: 0
h-index: 0
机构: BAYLOR COLL MED, CTR BIOTECHNOL, THE WOODLANDS, TX 77381 USA

HOGAN, ME
论文数: 0 引用数: 0
h-index: 0
机构: BAYLOR COLL MED, CTR BIOTECHNOL, THE WOODLANDS, TX 77381 USA
[10]
SELECTIVE STABILIZATION OF DNA TRIPLE HELICES BY BENZOPYRIDOINDOLE DERIVATIVES
[J].
ESCUDE, C
;
NGUYEN, CH
;
MERGNY, JL
;
SUN, JS
;
BISAGNI, E
;
GARESTIER, T
;
HELENE, C
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
1995, 117 (41)
:10212-10219

ESCUDE, C
论文数: 0 引用数: 0
h-index: 0
机构: MUSEUM NATL HIST NAT, BIOPHYS LAB, CNRS, URA 481, INSERM, U201, F-75231 PARIS 05, FRANCE

NGUYEN, CH
论文数: 0 引用数: 0
h-index: 0
机构: MUSEUM NATL HIST NAT, BIOPHYS LAB, CNRS, URA 481, INSERM, U201, F-75231 PARIS 05, FRANCE

MERGNY, JL
论文数: 0 引用数: 0
h-index: 0
机构: MUSEUM NATL HIST NAT, BIOPHYS LAB, CNRS, URA 481, INSERM, U201, F-75231 PARIS 05, FRANCE

SUN, JS
论文数: 0 引用数: 0
h-index: 0
机构: MUSEUM NATL HIST NAT, BIOPHYS LAB, CNRS, URA 481, INSERM, U201, F-75231 PARIS 05, FRANCE

BISAGNI, E
论文数: 0 引用数: 0
h-index: 0
机构: MUSEUM NATL HIST NAT, BIOPHYS LAB, CNRS, URA 481, INSERM, U201, F-75231 PARIS 05, FRANCE

GARESTIER, T
论文数: 0 引用数: 0
h-index: 0
机构: MUSEUM NATL HIST NAT, BIOPHYS LAB, CNRS, URA 481, INSERM, U201, F-75231 PARIS 05, FRANCE

HELENE, C
论文数: 0 引用数: 0
h-index: 0
机构: MUSEUM NATL HIST NAT, BIOPHYS LAB, CNRS, URA 481, INSERM, U201, F-75231 PARIS 05, FRANCE