Role of epithelial hyperplasia in regression following photorefractive keratectomy

被引:85
作者
Gauthier, CA
Holden, BA
Epstein, D
Tengroth, B
Fagerholm, P
HambergNystrom, H
机构
[1] UNIV NEW S WALES, SCH OPTOMETRY, CORNEA & CONTACT LENS RES UNIT, SYDNEY, NSW 2052, AUSTRALIA
[2] UNIV UPPSALA HOSP, DEPT OPHTHALMOL, UPPSALA, SWEDEN
[3] KAROLINSKA INST, ST ERIKS EYE HOSP, STOCKHOLM, SWEDEN
关键词
D O I
10.1136/bjo.80.6.545
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Aim-To determine the relation between epithelial hyperplasia and regression of Methods-Seventy unilaterally treated patients with PRK were examined. All eyes had been treated with the Summit excimer laser 27 (SD 7) months previously with zone diameters of 4.1 to 5.0 mm. The untreated fellow eyes served as controls. Epithelial thickness was measured centrally with a thin slit optical pachometer and manifest subjective refraction was performed. Results-The epithelium was 21% thicker in the treated eye (p<0.0001). The relation between refractive regression and epithelial hyperplasia was significant (r=0.41; p<0.001). Conclusions-Epithelial hyperplasia after PRK correlated with the myopic shift (including hyperopia reduction) after treatment with the Summit laser. A model is proposed suggesting that both subepithelial and epithelial layers contribute to regression in the Summit treated eyes with 18 mu m of epithelial hyperplasia contributing each dioptre of regression.
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收藏
页码:545 / 548
页数:4
相关论文
共 30 条
[1]   QUANTITATIVE HISTOLOGICAL STUDIES OF PRIMATE CORNEAS AFTER EXCIMER-LASER PHOTOREFRACTIVE KERATECTOMY [J].
BEUERMAN, RW ;
MCDONALD, MB ;
SHOFNER, RS ;
MUNNERLYN, CR ;
CLAPHAM, TN ;
SALMERON, B ;
KAUFMAN, HE .
ARCHIVES OF OPHTHALMOLOGY, 1994, 112 (08) :1103-1110
[2]   EXCIMER LASER PHOTOABLATION - CLINICAL-RESULTS AND TREATMENT OF COMPLICATIONS IN 1992 [J].
BINDER, PS .
ARCHIVES OF OPHTHALMOLOGY, 1992, 110 (09) :1221-1222
[3]  
CHANLING T, 1994, CONTACT LENS PRACTIC, P414
[4]   PHOTOREFRACTIVE KERATECTOMY FOR THE CORRECTION OF MYOPIA AND ASTIGMATISM [J].
COLLIAC, JP ;
SHAMMAS, HJ ;
BART, DJ .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 1994, 117 (03) :369-380
[5]  
COURANT D, 1990, LASERS LIGHT OPHTHAL, V3, P187
[6]   EXCIMER-LASER PHOTOREFRACTIVE KERATECTOMY WITH TAPERED TRANSITION ZONE FOR HIGH MYOPIA - A PRELIMINARY-REPORT OF 6 CASES [J].
DAUSCH, D ;
KLEIN, R ;
SCHRODER, E ;
DAUSCH, B .
JOURNAL OF CATARACT AND REFRACTIVE SURGERY, 1993, 19 (05) :590-594
[7]  
EPSTEIN D, 1993, OPHTHALMOLOGY, V100, P1605
[8]  
FAGERHOLM P, 1994, ACTA OPHTHALMOL, V72, P229
[9]   WOUND-HEALING AFTER EXCIMER LASER KERATOMILEUSIS (PHOTOREFRACTIVE KERATECTOMY) IN MONKEYS [J].
FANTES, FE ;
HANNA, KD ;
WARING, GO ;
POULIQUEN, Y ;
THOMPSON, KP ;
SAVOLDELLI, M .
ARCHIVES OF OPHTHALMOLOGY, 1990, 108 (05) :665-675
[10]  
FITZSIMMONS TD, 1992, INVEST OPHTH VIS SCI, V33, P3011