Examining the utility of patient-derived xenograft mouse models

被引：288

作者：

Aparicio, Samuel ^{[1
,2
]}

Hidalgo, Manuel ^{[3
]}

Kung, Andrew L. ^{[4
]}

机构：

[1] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V5Z 1L3, Canada

[2] BC Canc Agcy, Vancouver, BC V5Z 1L3, Canada

[3] Spanish Natl Canc Res Ctr CNIO, Clin Res Programme, Gastrointestinal Canc Clin Res Unit, Madrid 28029, Spain

[4] Columbia Univ, Med Ctr, Dept Pediat, New York, NY 10032 USA

来源：

NATURE REVIEWS CANCER | 2015年 / 15卷 / 05期

关键词：

NAB-PACLITAXEL; CANCER XENOGRAFTS; PANCREATIC-CANCER; TUMOR XENOGRAFTS; IDENTIFICATION; METASTASIS; RESISTANCE; GROWTH; GEMCITABINE; POPULATION;

D O I：

10.1038/nrc3944

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Patient-derived xenograft (PDX) models are now being widely used in cancer research and have the potential to greatly inform our understanding of cancer biology. However, many questions remain, especially regarding the ability of PDX models to affect clinical decision making. With these points in mind, we asked three scientists to give their opinions on the generation and uses of PDX models and the future of this field.

引用

页码：311 / 316

页数：6

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