Discriminated effects of thiolated chitosan-coated pMMA paclitaxel-loaded nanoparticles on different normal and cancer cell lines

被引：68

作者：

Akhlaghi, Seyedeh Parinaz ^{[1
]}

Saremi, Shahrooz ^{[1
]}

Ostad, Seyed Nasser ^{[1
]}

Dinarvand, Rassoul ^{[1
,2
]}

Atyabi, Fatemeh ^{[1
,2
]}

机构：

[1] Univ Tehran Med Sci, Fac Pharm, Tehran, Iran

[2] Med Sci Univ Tehran, Med Nanotechnol Res Ctr, Tehran, Iran

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2010年 / 6卷 / 05期

关键词：

Thiolated chitosan; Nanoparticles; Poly(methyl methacrylate); Paclitaxel; Cytotoxicity; IN-VITRO EVALUATION; ORAL DELIVERY; MUCOADHESION; ENHANCEMENT; THIOMERS; SYSTEM;

D O I：

10.1016/j.nano.2010.01.011

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The aim of the present work was to prepare and characterize poly(methyl methacrylate) nanoparticles coated by chitosan-glutathione conjugate so as to encapsulate insoluble anticancer drugs. Nanoparticles were synthesized through radical polymerization of methyl methacrylate initiated by cerium (IV) ammonium nitrate. Paclitaxel (PTX), a model anticancer drug, was encapsulated in nanoparticles with a maximal encapsulation efficiency of 98.27%. These nanoparticles showed sustained in vitro release of the incorporated PTX (75% of the loaded dose was released in 10 days). All nanoparticles had positive charge and were spherical, with a size range of about 130-250 nm. The PTX-loaded nanoparticles showed cytotoxicity for NIH 3T3 and T47D breast carcinoma cells, along with no cytotoxicity for two colon cell lines (HT29, Caco2).

引用

页码：689 / 697

页数：9

共 30 条

[1]

[Anonymous], 1996, MICROENCAPSULATION M

[2] Thiolated Chitosan Nanoparticles as an Oral Delivery System for Amikacin: In Vitro and Ex Vivo Evaluations [J].