Role of glutathione-dependent peroxidase in regulation of lipoperoxide utilization in malignant tumors

被引：7

作者：

Gorodzanskaya, EG ^{[1
]}

Larionova, VB ^{[1
]}

Zubrikhina, GN ^{[1
]}

Kormosh, NG ^{[1
]}

Davydova, TV ^{[1
]}

Laktionov, KP ^{[1
]}

机构：

[1] Russian Acad Med Sci, Blokhin Canc Res Ctr, Moscow 115478, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2001年 / 66卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

glutathione; glutathione-dependent enzymes; lipid peroxidation; malignant tumors;

D O I：

10.1023/A:1002803901075

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glutathione content, the activity of glutathione-dependent enzymes (glutathione reductase, glutathione peroxidase, and glutathione S-transferase), and also SOD (superoxide dismutase) and catalase were studied in human malignant tumors (uterus, breast, and ovaries) and normal tissues. Glutathione level and the activity of glutathione-dependent enzymes were 2-3 times higher in the malignant tumors than in normal tissues. A negative correlation between the level of glutathione and glutathione-dependent enzymes (glutathione peroxidase and glutathione S-transferase) in tumors and the efficacy of postoperative chemotherapy may characterize the degree of tumor resistance to chemotherapy and therefore may have prognostic value. Low SOD and catalase activity and high activity of glutathione-dependent enzymes in tumors suggest that glutathione peroxidase and glutathione S-transferase play a major role in peroxide utilization in malignant tumors.

引用

页码：221 / 224

页数：4

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