Adipocyte Heme Oxygenase-1 Induction Attenuates Metabolic Syndrome in Both Male and Female Obese Mice

被引：103

作者：

Burgess, Angela ^{[2
]}

Li, Ming ^{[2
]}

Vanella, Luca

Kim, Dong Hyun

Rezzani, Rita ^{[4
]}

Rodella, Luigi ^{[4
]}

Sodhi, Komal

Canestraro, Martina ^{[2
]}

Martasek, Pavel ^{[5
,6
]}

Peterson, Stephen J. ^{[2
,3
]}

Kappas, Attallah ^{[2
,7
]}

Abraham, Nader G. ^{[1
,2
,7
]}

机构：

[1] Univ Toledo, Coll Med, Dept Physiol & Pharmacol, Toledo, OH 43614 USA

[2] New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA

[3] New York Med Coll, Dept Med, Valhalla, NY 10595 USA

[4] Univ Brescia, Dept Biomed Sci & Biotechnol, Brescia, Italy

[5] Charles Univ Prague, Dept Pediat, Prague, Czech Republic

[6] Charles Univ Prague, Ctr Appl Genom, Prague, Czech Republic

[7] Rockefeller Univ, Pharmacol Lab, New York, NY 10021 USA

来源：

HYPERTENSION | 2010年 / 56卷 / 06期

基金：

美国国家卫生研究院;

关键词：

adipocyte pAMPK; female obesity; heme oxygenase inducers; inflammation;

D O I：

10.1161/HYPERTENSIONAHA.110.151423

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Increases in visceral fat are associated with increased inflammation, dyslipidemia, insulin resistance, glucose intolerance, and vascular dysfunction. We examined the effect of the potent heme oxygenase (HO)-1 inducer, cobalt protoporphyrin (CoPP), on regulation of adiposity and glucose levels in both female and male obese mice. Both lean and obese mice were administered CoPP intraperitoneally (3 mg/kg once per week) for 6 weeks. Serum levels of adiponectin, tumor necrosis factor alpha (TNFa), interleukin (IL)-1 beta and IL-6, and HO-1, PPAR gamma, pAKT, and pAMPK protein expression in adipocytes and vascular tissue were measured. While female obese mice continued to gain weight at a rate similar to controls, induction of HO-1 slowed the rate of weight gain in male obese mice. HO-1 induction led to lowered blood pressure levels in obese male and female mice similar to that of lean male and female mice. HO-1 induction also produced a significant decrease in the plasma levels of IL-6, TNF alpha, IL-1 beta, and fasting glucose of obese females compared to untreated female obese mice. HO-1 induction increased the number and decreased the size of adipocytes of obese animals. HO-1 induction increased adiponectin, pAKT, pAMPK, and PPAR gamma levels in adipocyte of obese animals. Induction of HO-1 in adipocytes was associated with an increase in adiponectin and a reduction in inflammatory cytokines. These findings offer the possibility of treating not only hypertension, but also other detrimental metabolic consequences of obesity including insulin resistance and dyslipidemia in obese populations by induction of HO-1 in adipocytes. (Hypertension. 2010;56:1124-1130.) . Online Data Supplement

引用

页码：1124 / U246

页数：17

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