Phenatic acids A and B, new potentiators of antifungal miconazole activity produced by Streptomyces sp K03-0132

被引：55

作者：

Fukuda, T

Matsumoto, A

Takahashi, Y

Tomoda, H

Omura, S

机构：

[1] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan

[2] Kitasato Univ, Grad Sch Infect Control Sci, Minato Ku, Tokyo 1088641, Japan

[3] Kitasato Inst, Minato Ku, Tokyo 1088642, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2005年 / 58卷 / 04期

关键词：

phenatic acids; phenol; azole potentiator; actinomycetes; actiphenol;

D O I：

10.1038/ja.2005.29

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two new phenols, designated phenatic acids A and B, were isolated along with known actiphenol, from the culture of Streptomyces sp. K03-0132 by solvent extraction, silica gel column chromatography and HPLC. Their structures were elucidated by spectroscopic analyses including mainly various NMR experiments. They have a common 1-hydroxy 2, 4-dimethyl benzene ring. These compounds potentiate miconazole activity against Candida albicans. Phenatic acid B also showed moderate antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Bacteroides fragilis and Acholeplasma laidlawii.

引用

页码：252 / 259

页数：8

共 17 条

[1] Funicone-related compounds, potentiators of antifungal miconazole activity, produced by Talaromyces flavus FKI-0076 [J].