Carbon nucleophile addition to sp2-unsaturated Fischer carbene complexes

被引：102

作者：

Barluenga, J ^{[1
]}

Flórez, J ^{[1
]}

Fañanás, FJ ^{[1
]}

机构：

[1] Univ Oviedo, Inst Quim Organomet Enrique Moles, Unidad Asociada, CSIC, E-33071 Oviedo, Spain

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2001年 / 624卷 / 1-2期

关键词：

Fischer carbene complexes; carbon nucleophilic addition; asymmetric synthesis;

D O I：

10.1016/S0022-328X(00)00837-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The reactions of group 6 (alkoxy)(aryl)- and (alkoxy)(alkenyl)carbene complexes with organolithium compounds, metal enolates, and enamines are summarized. (Alkoxy)(aryl)carbene complexes underwent mainly nucleophilic addition to the carbene carbon atom, but either 1,4- or 1,6-addition products have been observed with derivatives bearing a bulky alkoxy group and phenyl- or alkyllithimns. The more widely studied (alkoxy)(alkenyl)carbene complexes react with carbon nucleophiles to give 1,2- or 1,4-addition products depending on the steric surroundings of both the metal carbene complex and the nucleophile as well as the nature of the latter. These reactions have been employed for several useful carbon-carbon bond-forming processes taking place with high diastereoselectivity. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：5 / 17

页数：13

共 66 条

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