On the structure of total synthesis of complex natural products

被引：54

作者：

Whitlock, HW ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 22期

关键词：

D O I：

10.1021/jo9814546

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A chemically intuitive measure (metric) for molecular complexity is described. It is then applied to several syntheses of complex natural products. We conclude that the metric corresponds well with chemical ideas of complexity, and that different syntheses do in fact have appreciably different logical structures as measured by this. Possible implications of this interesting observation are discussed.

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页码：7982 / 7989

页数：8

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