Assembly of hereditary amyloid β-protein variants in the presence of favorable gangliosides

被引：58

作者：

Yamamoto, N

Hirabayashi, Y

Amari, M

Yamaguchi, H

Romanov, G

Van Nostrand, WE

Yanagisawa, K

机构：

[1] Natl Ctr Geriatr & Gerontol, Natl Inst Longev Sci, Dept Alzheimers Dis Res, Morioka, Iwate 4748522, Japan

[2] RIKEN, Neural Circuit Mechanism Res Grp, Brain Sci Inst, Wako, Saitama 3510198, Japan

[3] Geriatr REs Inst & Hosp, Maebashi, Gumma 3710847, Japan

[4] Gunma Univ, Sch Hlth Sci, Maebashi, Gumma 3718514, Japan

[5] SUNY Stony Brook, Dept Med, Hlth Sci Ctr, Stony Brook, NY 11794 USA

来源：

FEBS LETTERS | 2005年 / 579卷 / 10期

关键词：

Alzheimer's disease; cerebral amyloid angiopathy; amyloid; amyloid beta-protein; seed; ganglioside;

D O I：

10.1016/j.febslet.2005.03.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanisms underlying regional amyloid P-protein (A beta) deposition in brain remain unclear. Here we show that assembly of hereditary variant Dutch- and Italian-type A beta s, and Flemish-type A beta was accelerated by GM3 ganglioside, and GD3 ganglioside, respectively. Notably, cerebrovascular smooth muscle cells, which compose the cerebral vessel wall at which the Dutch- and Italian-type A beta s deposit, exclusively express GM3 whereas GD3 is upregulated in the co-culture of endothelial cells and astrocytes, which forms the cerebrovascular basement membrane, the site of Flemish-type A beta deposition. Our results suggest that regional A beta deposition is induced by the local gangliosides in the brain. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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收藏

页码：2185 / 2190

页数：6

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