The alleles of the DNA repair gene O6-alkylguanine-DNA alkyltransferase are expressed at different levels in normal human lung tissue

被引：12

作者：

Heighway, J

Margison, GP

Santibáñez-Koref, MF

机构：

[1] Christie Hosp NHS Trust, Paterson Inst Canc Res, Manchester M20 9BX, Lancs, England

[2] Roy Castle Int Ctr Lung Canc Res, Liverpool L3 9TA, Merseyside, England

[3] Inst Human Genet, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England

来源：

CARCINOGENESIS | 2003年 / 24卷 / 10期

关键词：

D O I：

10.1093/carcin/bgg124

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

O-6-Alkylguanine-DNA alkyltransferase (MGMT) confers resistance to many of the mutagenic and toxic effects of certain classes of alkylating agents by repairing the DNA lesions responsible. The levels of expression of this protein are of interest in relation to the prevention and treatment of cancer in man. They vary widely between individuals, and the basis of this variation is not understood. RT-PCR-RFLP analysis of mRNA from normal human lung tissue reveals that the two MGMT alleles are frequently expressed at different levels, indicating that there is a genetic component to inter-individual variation of MGMT levels and that at least some of this variation maps close to or within the MGMT locus.

引用

页码：1691 / 1694

页数：4

共 26 条

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[2]

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