Regulation and function of the p53 tumor suppressor protein

被引：597

作者：

Ryan, KM ^{[1
]}

Phillips, AC ^{[1
]}

Vousden, KH ^{[1
]}

机构：

[1] NCI, Regulat Cell Growth Lab, Frederick, MD 21702 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0955-0674(00)00216-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Loss of the p53 tumor suppressor pathway contributes to the development of most human cancers. p53 is a nuclear protein that functions as a regulator of transcription. Significant advances have been made recently in our understanding of how p53 function is regulated and the mechanisms by which p53 mediates its effects.

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页码：332 / 337

页数：6

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