Serum selenoprotein-P levels in patients with inflammatory bowel disease

Objective: Selenoprotein-P is a selenium-rich serum protein that carries more than 50% of serum selenium. We evaluated changes in serum selenoprotein-P levels in patients with inflammatory bowel disease. Methods: Serum selenoprotein-P levels were measured by enzyme-linked immunosorbent assay. Twenty healthy individuals (controls), 34 patients with ulcerative colitis, and 37 patients with Crohn's disease (CD) were studied. Results: A highly significant correlation was found between the serum selenium and selenoprotein-P levels. There was no significant difference in serum selenoprotein-P levels between healthy controls (average 3.4 ± 0.8 μ g/mL, n = 20) and patients with ulcerative colitis (3.0 ± 1.0 μ g/mL, n = 34). Serum selenoprotein-P levels were significantly lower in patients with CD (average 1.8 ± 0.5 μ g/mL, it = 37). Serum selenoprotein-P levels were significantly lower in the elemental diet group of patients who had CD (average 1.4 ± 0.4 μ g/mL, n = 17) than in the non-elemental diet group of patients who had CD (average 2.1 ± 0.3 Ag/mL, n 20). Conclusion: We found that the serum selenoprotein-P level is decreased in patients with CID. It may be a useful marker to monitor the systemic selenium status in various disorders. © 2005 Elsevier Inc. All rights reserved.