Lessons from anticancer research might provide new insights into mechanisms of hormone action

被引：4

作者：

Buckley, AR

机构：

[1] Univ Cincinnati, Ctr Med, Coll Pharm, Cincinnati, OH 45267 USA

[2] Univ Cincinnati, Ctr Med, Dept Mol & Cellular Physiol, Cincinnati, OH 45267 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2001年 / 12卷 / 03期

关键词：

D O I：

10.1016/S1043-2760(01)00380-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The extent to which specific anticancer drugs induce apoptosis in tumors frequently predicts the success of chemotherapy for a particular type of cancer. Recent results from experiments designed to evaluate drug-induced apoptosis in colon cancer cells revealed that the levels of BCL-2-related apoptotic suppressor proteins were dramatically reduced compared with those of pro-apoptotic proteins. In the case of nonsteroidal anti-inflammatory drugs, this might be a consequence of inhibition of the cyclooxygenase-mediated production of prostaglandins.

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页码：87 / 89

页数：3

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