Alkenyl- and aryl[2-(hydroxymethyl)phenyl]dimethylsilanes: An entry to tetraorganosilicon reagents for the silicon-based cross-coupling reaction

被引：185

作者：

Nakao, Y ^{[1
]}

Imanaka, H ^{[1
]}

Sahoo, AK ^{[1
]}

Yada, A ^{[1
]}

Hiyama, T ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Engn, Dept Chem Mat, Kyoto 6158510, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 19期

关键词：

D O I：

10.1021/ja051281j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Alkenyl- and aryl[2-(hydroxymethyl)phenyl]dimethylsilanes, highly stable tetraorganosilicon reagents, are found to react with aryl and alkenyl iodides in the presence of a palladium catalyst and K2CO3 as a base, significantly milder conditions compared with those ever reported for the silicon-based cross-coupling reactions. The reaction tolerates a wide range of functional groups, including silyl protectors, and allows a gram-scale synthesis to recover and reuse the silicon residue. Copyright © 2005 American Chemical Society.

引用

页码：6952 / 6953

页数：2

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