TH1-TH2:: a Procrustean paradigm

被引:187
作者
Gor, DO [1 ]
Rose, NR
Greenspan, NS
机构
[1] Boston Univ, Sch Med, Ctr Mol Stress Response, Boston, MA 02118 USA
[2] Case Western Reserve Univ, Inst Pathol, Cleveland, OH 44106 USA
[3] Johns Hopkins Univ, Dept Pathol, Baltimore, MD 21205 USA
[4] Johns Hopkins Univ, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA
关键词
D O I
10.1038/ni0603-503
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Although immunologists have found the dichotomous helper T cell subset model a useful construct, it is beginning to show its age. Some suggest that proponents of the T(H)1-T(H)2 dichotomy are overzealous in making the data conform to the scheme, like Procrustes who stretched or truncated his guests so that they would fit his guest bed.
引用
收藏
页码:503 / 505
页数:3
相关论文
共 18 条
[1]   Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-γ-independent pathway [J].
Afanasyeva, M ;
Wang, Y ;
Kaya, Z ;
Stafford, EA ;
Dohmen, KM ;
Akha, AAS ;
Rose, NR .
CIRCULATION, 2001, 104 (25) :3145-3151
[2]   Experimental autoimmune myocarditis in A/J mice is an interleukin-4-dependent disease with a Th2 phenotype [J].
Afanasyeva, M ;
Wang, Y ;
Kaya, Z ;
Park, S ;
Zilliox, MJ ;
Schofield, BH ;
Hill, SL ;
Rose, NR .
AMERICAN JOURNAL OF PATHOLOGY, 2001, 159 (01) :193-203
[3]   Th1-Th2: reliable paradigm or dangerous dogma? [J].
Allen, JE ;
Maizels, RM .
IMMUNOLOGY TODAY, 1997, 18 (08) :387-392
[4]   CD40L-Induced IL-12 production is further enhanced by the Th2 cytokines IL-4 and IL-13 [J].
Bullens, DMA ;
Kasran, A ;
Thielemans, K ;
Bakkus, M ;
Ceuppens, JL .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2001, 53 (05) :455-463
[5]  
CHER DJ, 1987, J IMMUNOL, V138, P3688
[6]   T regulatory cells 1 inhibit a Th2-specific response in vivo [J].
Cottrez, F ;
Hurst, SD ;
Coffman, RL ;
Groux, H .
JOURNAL OF IMMUNOLOGY, 2000, 165 (09) :4848-4853
[7]  
Ferber IA, 1996, J IMMUNOL, V156, P5
[8]   Single-cytokine-producing CD4 memory cells predominate in type 1 and type 2 immunity [J].
Karulin, AY ;
Hesse, MD ;
Tary-Lehmann, M ;
Lehmann, PV .
JOURNAL OF IMMUNOLOGY, 2000, 164 (04) :1862-1872
[9]   Cutting edge: A critical role for IL-10 in induction of nasal tolerance in experimental autoimmune myocarditis [J].
Kaya, Z ;
Dohmen, KM ;
Wang, Y ;
Schlichting, J ;
Afanasyeva, M ;
Leuschner, F ;
Rose, NR .
JOURNAL OF IMMUNOLOGY, 2002, 168 (04) :1552-1556
[10]   Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease [J].
Lafaille, JJ ;
VandeKeere, F ;
Hsu, AL ;
Baron, JL ;
Haas, W ;
Raine, CS ;
Tonegawa, S .
JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (02) :307-312