Massed practice versus massed practice with a stimulation: Effects on upper extremity function and cortical plasticity in individuals with incomplete cervical spinal cord injury

Objective. To determine the effect of massed practice (MP) versus massed practice combined with somatosensmy stimulation (MP+SS) on cortical plasticity and function in per sons with incomplete tetraplegia. Methods. Ten subjects were assigned to either MP or MP+SS. Mediam nerve stimulation (500 ms train, 10 Hz, I ms pulse duration) was delivered at the intensity eliciting a motor threshold response, Training sessions were 5 d/week for 3 weeks at 2 h/session. Outcome measures included 1) motor evoked potentials (MEPs) elicited via transcranial magnetic stimulation (TMS), motor threshold (MT) and MEP amplitude at 1.2x MT; 2) maximal pinch grip force; 3) Wolf Motor Function Test (WMFT) and jebsen Hand Function Test. Results. The MP+SS group demonstrated significant improvements (P < 0.05) in pinch grip strength (190%), WMFT scores (52%), andjebsen test scores (33%), whereas the MP group demonstrated significant improvement (P < 0.05) only in Jebsen test scores (11%). No significant changes were detected in cortical excitability in the MP+SS or MP group. Conclusions. The findings of this preliminary study suggest that MP+SS results in greater increases in pinch strength and timed Junctional test scores than ME Optimal stimulation paradigms and training methods are needed to further test this strategy.