Analysis of the murine Dtk gene identifies conservation of genomic structure within a new receptor tyrosine kinase subfamily

被引：15

作者：

Lewis, PM

Crosier, KE

Wood, CR

Crosier, PS

机构：

[1] UNIV AUCKLAND,SCH MED,DEPT MOLEC MED,AUCKLAND,NEW ZEALAND

[2] GENET INST INC,CAMBRIDGE,MA 02140

来源：

GENOMICS | 1996年 / 31卷 / 01期

关键词：

D O I：

10.1006/geno.1996.0003

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The receptor tyrosine kinase Dtk/Tyro 3/Shy/rse/brt/tif is a member of a new subfamily of receptors that also includes Axl/Ufo/Ark and Eyk/Mer. These receptors are characterized by the presence of two immunoglobulin-like loops and two fibronectin type III repeats in their extracellular domains. The structure of the murine Dtk gene has been determined. The gene consists of 21 exons that are distributed over 21 kb of genomic DNA. An isoform of Dtk is generated by differential splicing of exons hem the 5' region of the gene. The overall genomic structure of Dth is virtually identical to that determined for the human UFO gene. This particular genomic organization is likely to have been duplicated and closely maintained throughout evolution. (C) 1996 Academic Press, Inc

引用

页码：13 / 19

页数：7

共 38 条

[1]

ANDRE C, 1992, ONCOGENE, V7, P685

[2] GENERATION OF PROTEIN ISOFORM DIVERSITY BY ALTERNATIVE SPLICING - MECHANISTIC AND BIOLOGICAL IMPLICATIONS [J].

ANDREADIS, A ;

GALLEGO, ME ;

NADALGINARD, B .

ANNUAL REVIEW OF CELL BIOLOGY, 1987, 3 :207-242

[3]

BIESECKER LG, 1995, ONCOGENE, V10, P2239

[4] ONCOGENES AND SIGNAL TRANSDUCTION [J].

CANTLEY, LC ;

AUGER, KR ;

CARPENTER, C ;

DUCKWORTH, B ;

GRAZIANI, A ;

KAPELLER, R ;

SOLTOFF, S .

CELL, 1991, 64 (02) :281-302

[5]

CERVELLA P, 1993, J BIOL CHEM, V268, P5148

[6] ISOLATION AND CHARACTERIZATION OF THE HUMAN DTK RECEPTOR TYROSINE KINASE [J].

CROSIER, KE ;

HALL, LR ;

LEWIS, PM ;

MORRIS, CM ;

WOOD, CR ;

MORRIS, JC ;

CROSIER, PS .

GROWTH FACTORS, 1994, 11 (02) :137-144

[7] ISOLATION OF A RECEPTOR TYROSINE KINASE (DTK) FROM EMBRYONIC STEM-CELLS - STRUCTURE, GENETIC-MAPPING AND ANALYSIS OF EXPRESSION [J].

CROSIER, PS ;

LEWIS, PM ;

HALL, LR ;

VITAS, MR ;

MORRIS, CM ;

BEIER, DR ;

WOOD, CR ;

CROSIER, KE .

GROWTH FACTORS, 1994, 11 (02) :125-136

[8]

DAI W, 1994, ONCOGENE, V9, P975

[9] CELL-ADHESION MOLECULES - IMPLICATIONS FOR A MOLECULAR HISTOLOGY [J].

EDELMAN, GM ;

CROSSIN, KL .

ANNUAL REVIEW OF BIOCHEMISTRY, 1991, 60 :155-190

[10]

FAUST M, 1992, ONCOGENE, V7, P1287

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