Vascular biology - Targeted delivery of nitric oxide

被引:44
作者
Gross, SS [1 ]
机构
[1] Cornell Univ, Coll Med, Dept Pharmacol, New York, NY 10021 USA
关键词
D O I
10.1038/35054661
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Nitric oxide is a biological signalling gas that has been assumed to reach its protein targets by simple random diffusion. The discovery of molecular mechanisms for precise nitric oxide delivery challenges that assumption.
引用
收藏
页码:577 / 578
页数:3
相关论文
共 10 条
[1]   Dexras1: A G protein specifically coupled to neuronal nitric oxide synthase via CAPON [J].
Fang, M ;
Jaffrey, SR ;
Sawa, A ;
Ye, KQ ;
Luo, XJ ;
Snyder, SH .
NEURON, 2000, 28 (01) :183-193
[2]   Reactions between nitric oxide and haemoglobin under physiological conditions [J].
Gow, AJ ;
Stamler, JS .
NATURE, 1998, 391 (6663) :169-173
[3]   Physiological reactions of nitric oxide and hemoglobin: A radical rethink [J].
Gross, SS ;
Lane, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (18) :9967-9969
[4]   S-nitrosohaemoglobin: A dynamic activity of blood involved in vascular control [J].
Jia, L ;
Bonaventura, C ;
Bonaventura, J ;
Stamler, JS .
NATURE, 1996, 380 (6571) :221-226
[5]   Intravascular flow decreases erythrocyte consumption of nitric oxide [J].
Liao, JC ;
Hein, TW ;
Vaughn, MW ;
Huang, KT ;
Kuo, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (15) :8757-8761
[6]   Diffusion-limited reaction of free nitric oxide with erythrocytes [J].
Liu, XP ;
Miller, MJS ;
Joshi, MS ;
Sadowska-Krowicka, H ;
Clark, DA ;
Lancaster, JR .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (30) :18709-18713
[7]   Export by red blood cells of nitric oxide bioactivity [J].
Pawloski, JR ;
Hess, DT ;
Stamler, JS .
NATURE, 2001, 409 (6820) :622-626
[8]   (S)NO signals: Translocation, regulation, and a consensus motif [J].
Stamler, JS ;
Toone, EJ ;
Lipton, SA ;
Sucher, NJ .
NEURON, 1997, 18 (05) :691-696
[9]   Erythrocytes possess an intrinsic barrier to nitric oxide consumption [J].
Vaughn, MW ;
Huang, KT ;
Kuo, L ;
Liao, JC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (04) :2342-2348
[10]  
WALDER JA, 1984, J BIOL CHEM, V259, P238