Risk of breast cancer among Norwegian women with visual impairment

被引：78

作者：

Kliukiene, J ^{[1
]}

Tynes, T

Andersen, A

机构：

[1] Canc Registry Norway, N-0310 Oslo, Norway

[2] Norwegian Radiat Protect Author, N-0407 Oslo, Norway

来源：

BRITISH JOURNAL OF CANCER | 2001年 / 84卷 / 03期

关键词：

blindness; visual impairment; breast cancer; melatonin;

D O I：

10.1054/bjoc.2000.1617

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Experimental studies suggest that melatonin has a protective effect against breast cancer. Exposure to light suppresses melatonin secretion, but to a lesser degree in totally blind persons. Breast cancer was investigated in a cohort of 15 412 Norwegian visually impaired women. The risk among totally blind women was 0.64 (95% CI = 0.21-1.49, 5 cases only), and for those who became blind before age of 65, the SIR was 0.51 (95% CI = 0.11-1.49). Our findings give support to the 'melatonin hypothesis'. (C) 2001 Cancer Research Campaign.

引用

页码：397 / 399

页数：3

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