Distribution of biochemical markers in biologic fluids - Application to the postmortem diagnosis of myocardial infarction

被引：21

作者：

Osuna, E ^{[1
]}

Perez-Carceles, MD ^{[1
]}

Vieira, DN ^{[1
]}

Luna, A ^{[1
]}

机构：

[1] Univ Murcia, Dept Forens Med, E-30100 Espinardo, Murcia, Spain

来源：

AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY | 1998年 / 19卷 / 02期

关键词：

myocardial infarction; biochemistry; postmortem; pericardial fluid;

D O I：

10.1097/00000433-199806000-00005

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

We evaluated the usefulness of postmortem determination of biochemical markers and the ratio of their concentrations in pericardial fluid and serum to diagnose acute myocardial necrosis. One hundred cadavers from routine necropsies were studied. Cases were allocated in diagnostic groups according to the cause of death. Myoglobin and myosin heavy chain concentrations and creatine kinase MB isoenzymes (CK-MB) activities were measured in serum and pericardial fluid. Ratios of the concentrations obtained in these fluids were calculated. Hematoxylin and eosin (H&E) and acridine orange stains were used for microscopy studies. Pericardial fluid-serum ratios of the concentrations of biochemical markers were significantly different. The ratio of the concentrations of myosin is the best indicator of widespread muscle damage or cardiac necrosis.

引用

页码：123 / 128

页数：6

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