Stem cell transplantation for congenital immunodeficiencies using reduced-intensity conditioning

被引：26

作者：

Veys, P ^{[1
]}

Rao, K ^{[1
]}

Amrolia, P ^{[1
]}

机构：

[1] Great Ormond St Hosp Children NHS Trust, London WC1N 3JH, England

来源：

BONE MARROW TRANSPLANTATION | 2005年 / 35卷 / Suppl 1期

关键词：

reduced-intensity conditioning (RIC); stem cell transplantation (SCT); immunodeficiency;

D O I：

10.1038/sj.bmt.1704846

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The optimal preparation for stem cell transplantation (SCT) in children with congenital immunodeficiencies is currently unknown. In all, 81 children with immunodeficiency underwent 82 SCTs using reduced-intensity conditioning (RIC). The incidence of significant GVHD was low; viral reactivation was prominent with an unexpected increase in EBV reactivation; immune reconstitution was similar between different donor groups and comparable to conventional SCT. Overall, 68/81 (84%) survive with no significant difference between donor types or between severe combined immunodeficiency ( SCID) and non-SCID diseases. Findings suggest a significant survival advantage in the unrelated donor setting for RIC compared to conventional SCT.

引用

页码：S45 / S47

页数：3