Xenon as neuroprotectant in acute stroke?

被引：8

作者：

Altschuler, EL ^{[1
]}

机构：

[1] Univ Calif San Diego, Brain & Percept Lab, La Jolla, CA 92093 USA

来源：

MEDICAL HYPOTHESES | 2001年 / 56卷 / 02期

关键词：

D O I：

10.1054/mehy.2000.1159

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Stroke is one of the most common diseases worldwide. A current focus of research is to find neuroprotectants that can be given during acute stroke. One specific target is to find antagonists of the N-methyl-D-aspartate (NMDA) receptor in an attempt to limit glutamate associated neurotoxicity. Xenon has recently been found to be an NMDA receptor antagonist. I suggest that xenon be considered as a neuroprotectant in acute stroke, and discuss methods of testing this proposal. (C) 2001 Harcourt Publishers Ltd.

引用

页码：227 / 228

页数：2

共 7 条

[1] Rehabilitation of hemiparesis after stroke with a mirror [J].

Altschuler, EL ;

Wisdom, SB ;

Stone, L ;

Foster, C ;

Galasko, D ;

Llewellyn, DME ;

Ramachandran, VS .

LANCET, 1999, 353 (9169) :2035-2036

[2] THE ANESTHETIC PROPERTIES OF XENON IN ANIMALS AND HUMAN BEINGS, WITH ADDITIONAL OBSERVATIONS ON KRYPTON [J].

CULLEN, SC ;

GROSS, EG .

SCIENCE, 1951, 113 (2942) :580-582

[3] How does xenon produce anaesthesia? [J].

Franks, NP ;

Dickinson, R ;

de Sousa, SLM ;

Hall, AC ;

Lieb, WR .

NATURE, 1998, 396 (6709) :324-324

[4]

Gengo FM, 1998, PHARMACOTHERAPY, V18, p101S

[5]

Kwatkowski TG, 1999, NEW ENGL J MED, V340, P1781

[6]

LAWRENCE JH, 1947, J PHYSIOL-LONDON, V105, P197

[7]

TAUB E, 1993, ARCH PHYS MED REHAB, V74, P347

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