Perinatal photoperiod imprints the circadian clock

被引:120
作者
Ciarleglio, Christopher M. [1 ,2 ]
Axley, John C. [2 ]
Strauss, Benjamin R. [2 ]
Gamble, Karen L. [2 ]
McMahon, Douglas G. [1 ,2 ]
机构
[1] Vanderbilt Univ, Neurosci Grad Program, Nashville, TN 37203 USA
[2] Vanderbilt Univ, Dept Biol Sci, Nashville, TN USA
基金
美国国家卫生研究院;
关键词
MOUSE SUPRACHIASMATIC NUCLEUS; LIGHT; PACEMAKER; RESPONSES; BEHAVIOR; PERIOD;
D O I
10.1038/nn.2699
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
Using real-time gene expression imaging and behavioral analysis, we found that the perinatal photoperiod has lasting effects on the circadian rhythms expressed by clock neurons as well as on mouse behavior, and sets the responsiveness of the biological clock to subsequent changes in photoperiod. These developmental gene x environment interactions tune circadian clock responses to subsequent seasonal photoperiods and may contribute to the influence of season on neurobehavioral disorders in humans.
引用
收藏
页码:25 / 27
页数:3
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