Management of venous thromboembolism in patients with glioma

被引：29

作者：

Al Megren, Mosaad ^{[1
]}

De Wit, Carine ^{[3
]}

Al Qahtani, Mohammad ^{[2
]}

Le Gal, Gregoire ^{[3
]}

Carrier, Marc ^{[3
]}

机构：

[1] Al Imam Mohammad Ibn Saud Islamic Univ, Coll Med, Riyadh, Saudi Arabia

[2] King Abdul Aziz Med City, Dept Med, Riyadh, Saudi Arabia

[3] Univ Ottawa, Ottawa Hosp Res Inst, Dept Med, Ottawa, ON, Canada

来源：

THROMBOSIS RESEARCH | 2017年 / 156卷

关键词：

Glioma; venous thromboembolism; venous thrombosis; hemorrhage; neoplasm; HIGH-GRADE GLIOMA; INTRACRANIAL HEMORRHAGE; BRAIN METASTASES; GLIOBLASTOMA; THERAPY;

D O I：

10.1016/j.thromres.2017.06.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Venous thromboembolism(VTE) is a common complication among patients with glioma. However, data on the safety of therapeutic doses of anticoagulation is scarce in this patient population. Objectives: The purpose of this study is to evaluate the risk of intracranial hemorrhage (ICH) in glioma patients receiving therapeutic anticoagulation for VTE treatment. Patients and methods: We conducted a case-control study including glioma patients with and without acute VTE from Jan 2010 to March 2015. Controls were matched based on age, gender and tumor grade. Result: 569 patients with glioma were identified, 76 (13.3%) developed acute VTE. Of the 70 patients treated with full dose anticoagulant therapy, 14 (20%) patients had a major bleeding including 11 (15.7%) ICH. The odds ratio for ICH in patients with glioma and VTE who were treated with anticoagulation compared to the control group was 7.5 (95% CI, 1.6-34.9) p = 0.01. Overall survival was similar for VTE and control group (36 vs. 42 months, p = 0.93). Conclusion: Therapeutic anticoagulation is associated with a 7-fold increase risk of ICH in glioma patients. Data emerging from this study support the need for high quality studies to evaluate the risk of ICH in patients with glioma and VTE. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：105 / 108

页数：4

共 14 条

[1] Intracranial hemorrhage in patients with brain metastases treated with therapeutic enoxaparin: a matched cohort study [J].

Donato, Jessica ;

Campigotto, Federico ;

Uhlmann, Erik J. ;

Coletti, Erika ;

Neuberg, Donna ;

Weber, Griffin M. ;

Zwicker, Jeffrey I. .

BLOOD, 2015, 126 (04) :494-499

[2] Recurrent venous thromboembolism in glioblastoma [J].

Edwin, Natasha Catherine ;

Khoury, Michael N. ;

Sohal, Davendra ;

McCrae, Keith R. ;

Ahluwalia, Manmeet S. ;

Khorana, Alok A. .

THROMBOSIS RESEARCH, 2016, 137 :184-188

[3] RISK-FACTORS FAR INTRACRANIAL HEMORRHAGE IN OUTPATIENTS TAKING WARFARIN [J].

HYLEK, EM ;

SINGER, DE .

ANNALS OF INTERNAL MEDICINE, 1994, 120 (11) :897-902

[4]

Khoury M.N., 2015, NEUROONCOL PRACT, P1

[5] COMPLICATIONS OF THERAPY FOR VENOUS THROMBOEMBOLIC DISEASE IN PATIENTS WITH BRAIN-TUMORS [J].

LEVIN, JM ;

SCHIFF, D ;

LOEFFLER, JS ;

FINE, HA ;

BLACK, PM ;

WEN, PY .

NEUROLOGY, 1993, 43 (06) :1111-1114

[6] Sentinel Lymph Node Biopsy for Patients With Early-Stage Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update [J].

Lyman, Gary H. ;

Temin, Sarah ;

Edge, Stephen B. ;

Newman, Lisa A. ;

Turner, Roderick R. ;

Weaver, Donald L. ;

Benson, Al B., III ;

Bosserman, Linda D. ;

Burstein, Harold J. ;

Cody, Hiram, III ;

Hayman, James ;

Perkins, Cheryl L. ;

Podoloff, Donald A. ;

Giuliano, Armando E. .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (13) :1365-+

[7]

Pan E, 2009, ANTICANCER RES, V29, P4309

[8] THROMBOEMBOLISM IN PATIENTS WITH HIGH-GRADE GLIOMA [J].

QUEVEDO, JF ;

BUCKNER, JC ;

SCHMIDT, JL ;

DINAPOLI, RP ;

OFALLON, JR .

MAYO CLINIC PROCEEDINGS, 1994, 69 (04) :329-332

[9]

SCHIFF D, 1994, CANCER, V73, P493, DOI 10.1002/1097-0142(19940115)73:2<493::AID-CNCR2820730240>3.0.CO

[10]

2-D

← 1 2 →