Synthesis of amphiphilic galactopyranosyl diamines and amino alcohols as antitubercular agents

被引：22

作者：

de Almeida, Mauro Vieira ^{[1
]}

Le Hyaric, Mireille

Amarante, Giovanni Wilson

Silva Lourenco, Maria Cristina

Lima Brandao, Marcelo Luiz

机构：

[1] Fed Univ Juiz Fora, Dept Quim, BR-36036330 Juiz De Fora, MG, Brazil

[2] Fundacao Oswaldo Cruz, IPEC, Inst Pesquisa Clin Evandro Chagas, BR-21041250 Rio De Janeiro, Brazil

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2007年 / 42卷 / 08期

关键词：

D-Galactose; surfactant; N-alkyl-diamine; N-alkyl-ethanotamine; tuberculosis;

D O I：

10.1016/j.ejmech.2007.01.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Mono-and diacylated derivatives of galactopyranosyl amines were obtained from D-galactose, via aminated intermediates prepared by reaction of 6-deoxy-6-iodo-1,2:3,4-di-O-isopropylidene-alpha-D-galactopyranose with 1,3-propanediamine, 1,2-ethanediamine or ethanolamine. Monoacylated derivatives displayed antitubercular activity. (c) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：1076 / 1083

页数：8

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