The Polycomb group - no longer an exclusive club?

被引：135

作者：

Brock, HW

van Lohuizen, M

机构：

[1] Univ British Columbia, Dept Zool, Vancouver, BC V6T 1Z4, Canada

[2] Netherlands Canc Inst, Antoni Van Leeuwenhoek Hosp, Dept Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2001年 / 11卷 / 02期

关键词：

D O I：

10.1016/S0959-437X(00)00176-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Polycomb group (PcG) proteins maintain silencing at target loci in higher eukaryotes but recent evidence suggests that about half of these proteins are also required for maintenance of activation at homeotic loci, We suggest that PcG and trithorax group response elements should acquire a new name, 'maintenance elements', to reflect the dual function of regulatory elements that bind both groups of proteins, New data suggest that there might be a functional link between PcG repression and cell-cycle regulation.

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页码：175 / 181

页数：7

相关论文

共 68 条

[1]

Akasaka T, 1996, DEVELOPMENT, V122, P1513

[2] The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors [J].

Akasaka, T ;

Tsuji, K ;

Kawahira, H ;

Kanno, M ;

Harigaya, K ;

Hu, LN ;

Ebihara, Y ;

Nakahata, T ;

Tetsu, O ;

Taniguchi, M ;

Koseki, H .

IMMUNITY, 1997, 7 (01) :135-146

[3] Chromodomains are protein-RNA interaction modules [J].

Akhtar, A ;

Zink, D ;

Becker, PB .

NATURE, 2000, 407 (6802) :405-409

[4] Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian Polycomb complex [J].

Alkema, MJ ;

Bronk, M ;

Verhoeven, E ;

Otte, A ;

vantVeer, LT ;

Berns, A ;

vanLohuizen, M .

GENES & DEVELOPMENT, 1997, 11 (02) :226-240

[5]

Bel S, 1998, DEVELOPMENT, V125, P3543

[6]

BHAT KM, 1996, DEVELOPMENT, V122, P1513

[7] The Drosophila polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1 [J].

Brown, JL ;

Mucci, D ;

Whiteley, M ;

Dirksen, ML ;

Kassis, JA .

MOLECULAR CELL, 1998, 1 (07) :1057-1064

[8] The distribution of polycomb-group proteins during cell division and development in Drosophila embryos:: Impact on models for silencing [J].

Buchenau, P ;

Hodgson, J ;

Strutt, H ;

Arndt-Jovin, DJ .

JOURNAL OF CELL BIOLOGY, 1998, 141 (02) :469-481

[9] TRANSCRIPTIONAL REPRESSION BY DROSOPHILA AND MAMMALIAN POLYCOMB GROUP PROTEINS IN TRANSFECTED MAMMALIAN-CELLS [J].

BUNKER, CA ;

KINGSTON, RE .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (03) :1721-1732

[10] GENETIC INTERACTIONS AND DOSAGE EFFECTS OF POLYCOMB GROUP GENES OF DROSOPHILA [J].

CAMPBELL, RB ;

SINCLAIR, DAR ;

COULING, M ;

BROCK, HW .

MOLECULAR & GENERAL GENETICS, 1995, 246 (03) :291-300

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